| dc.description.abstract | Acupuncture helps the cell regeneration process in the langerhans island of the pancreas.
This process is through inhibition of TNF-α pro-inflammatory cytokine secretion and also decreases the
apoptosis process. This study aims to determine the potential for acupuncture in ST36 acupuncture
points on TNF-α expression and apoptosis in diabetic wistar rat pancreas. Method: Forty-two Wistar
rats, 3 months old, were divided into 5 groups, negative controls (decapitated 7th and 30th days), positive
controls (decapitated 7th and 30th days), treatment (decapitated 7th and 30th days). Rat were made
with a diabetic condition by injected streptozotocin at a dose of 60 mg / kg bodyweight in
intraperitoneal. The positive group and treatment were made in diabetes conditions, the treatment
group was stabbed in ST36 acupuncture points. After decapitating each group on the 7th and 30th days,
pancreas tissue was fixed and made preparations and given immunohistochemical staining and TUNNEL.
The number of cells expressing TNF-α and experiencing apoptosis were calculated per 10 visual fields
using 400 x magnification light microscopy, then the data were analyzed. Results: Acupuncture at the
ST36 point decreased the inflammatory process in the pancreas with diabetic rat, the effect of the
acupuncture at the ST36 point showed no direct correlation with the number of apoptotic beta cells.
Conclusion: Acupuncture needle puncture in the ST36 acupuncture point decreases inflammation and
apoptotic process in the rat pancreas with diabetes condition. | en_US |
