EFFECT OF EPIGALLOCATECHIN-3-GALLATE ON IL-1β LEVELS IN INJURED SKIN INFECTED BY Pseudomonas aeruginosa

Abstract

Epigallocatechin-3-gallate (EGCG) is a polyphenol compound from green tea, which has an antibacterial, antioxidant, anti-inflammatory, and stimulating growth effect of keratinocytes. The antibacterial effect of creams containing EGCG applied to wounds infected with Pseudomonas aeruginosa is expected to kill the bacteria. With the death of the bacterium Pseudomonas aeruginosa, pro-inflammatory cytokines interleukin-1β (IL-1β) produced by inflammatory cells can be controlled and lowered so that triggers the proliferation of keratinocytes to close wounds. The results of this study indicated that the administration of creams containing EGCG reduced IL-1β levels in wound infected with Pseudomonas aeruginosa on the skin of rats.