| dc.description.abstract | Keloid is a benign fibroproliferative
disease caused by an abnormal response to skin injury,
including trauma, acne vulgaris, chickenpox, and many
others. In multiple eruptive keloids, many papules and
plaques may form simultaneously over one or more
anatomical regions causing a disfiguring look. Keloids
are also recalcitrant to treatment and tend to recur many
times, especially with monotherapy. Intralesional injection of steroid suspension has been the first‐line therapy
for many years due to its ability to inhibit fibroblast
growth and induce collagen breakdown but require
multiple treatments and can result in skin atrophy,
telangiectasia, pigmentary changes, and systemic effects
such as Cushing's syndrome. The risk of complications is
even greater when high cumulative dosages are used
in multiple keloid lesions. With the dawn of Laser
technology, ablative fractional carbon dioxide laser is an
encouraging new option with the ability to modulate
cellular growth factors to prevent excessive formation of
collagen bundles. However, the ablative fractional Laser
still requires many treatments with a high recurrence
rate. In this case series, we seek to improve the efficacy
and safety of the treatment of eruptive keloid by
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10969101, 2022, S34, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/lsm.23536 by INASP/HINARI - INDONESIA, Wiley Online Library on [07/11/2022]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
combining intralesional steroid suspension injections
with ablative fractional carbon dioxide (CO2) laser.
Study Design/Materials and Method: Five patients
with eruptive keloids on the chest were treated using a
combination of ablative fractional CO2 laser and
intralesional injections of steroid suspension. Both Laser
procedures and injections were done every 4 weeks for 12
weeks. Clinical follow‐up was focused on the total
number of lesions and the volume of each keloid lesion. | en_US |
