| dc.description.abstract | Liver damage continues to be a prevailing global health issue. Primary risk factors
to liver impairment encompass excessive alcohol consumption. According to the National AntiAlcohol Movement in 2014, it was disclosed that 23% of 14.4 million adolescents in Indonesia
consumed alcohol, indicating a substantial increase compared to 2007. With the progression
of scientific knowledge, herbal plants such as Moringa oleifera leaves have been extensively
utilized for medicinal purposes due to their content of phytochemical compounds like
flavonoids, glucosinolates, isothiocyanates, and phenolic acids, which play crucial roles as
antioxidants and anti-inflammatory agents. The aim of this research is to examine the influence
of ethanol extract from Moringa oleifera leaves on the histological depiction of the livers of
white rats (Rattus norvegicus) exposed to alcohol. The research method involved 25 rats
divided into five groups, each consisting of 5 rats. The negative control group (K-) received
standard feed and water, the positive control group (K+) received 25% alcohol, and three
other groups received 25% alcohol along with Moringa oleifera leaf extract at three different
doses (250 mg/kgBW, 500 mg/kgBW, and 1000 mg/kgBW) for 21 days. The research findings
highlight a significant disparity in terms of necrotic cells, with K+ displaying 22.4 hepatocyte
necrosis, K1 with 20.8 hepatocyte necrosis, K2 with 13.2 hepatocyte necrosis, and K3 with 6.2
hepatocyte necrosis. The K+ and K1 groups experienced more substantial hepatic damage
compared to the K-, K2, and K3 groups. Meaningful improvements were notably evident,
especially in the treatment group receiving Moringa oleifera leaf extract at a dose of 1000
mg/kgBW, indicating the involvement of the dose of Moringa oleifera leaf extract as a factor
influencing the level of hepatocyte cell recovery. | en_US |
